Walker with muscle: A paper by Kaya and Higuchi from the University of Tokyo discussed how myosin motors, the active force-generating machines in muscle, adjust their walking steps with non-linear elasticity.1 Myosins work together in muscle. Their ability to reduce stiffness and adjust their walk is essential: “the load-dependent changes in the step size are an essential property of skeletal myosin,” the authors said. Their last sentence explained why this contributes to their effectiveness: “Such molecular properties may be inherent in the assembly of molecular motors and may reduce molecular interference, leading to the high mechanical efficiency of muscle contraction.” You have your elastic myosins to thank for every simple or complex move you make. For more stories about myosin this year, see 04/19/2010, 02/19/2010, and 01/19/2010.Junk with control: It wasn’t long ago when any non-coding region of the genome was considered junk. No longer; lincRNAs are emerging as stars of regulation and control (see 08/02/2010). Another finding to that effect was published in Science by an international team from Stanford, Harvard and the Weizmann Institute in Israel.2 They studied one lincRNA called HOTAIR that has two specific binding domains for making histone modifications. Histone is the protein on which DNA winds. It contains molecular tags that affect translation – the “histone code” (see 12/22/2009, bullet 5, with its embedded links). The team found that HOTAIR, an RNA generated from non-coding DNA, is intimately involved with the regulation of histone by forming a scaffold for PRC2 and LSD1 proteins: “The functional consequence of coordinate targeting of PRC2 and LSD1 by HOTAIR is gene repression,” they said. What they found may apply to other cases: “Some lincRNAs may be ‘tethers’ that recruit several chromatin modifications to their sites of synthesis while other lincRNAs can act on distantly located genes as ‘guides’ to affect their chromatin states,” the concluded. “On the basis of their dynamic patterns of expression, specific lincRNAs can potentially direct complex patterns of chromatin states at specific genes in a spatially and temporally organized manner during development and disease states.”Repairmen with teamwork: A team at Zheijiang University in China studied the partners in DNA interstrand cross-link repair, one of many repair pathways active in the genome. Fanconi anemia is a disease caused by mutations in 13 Fanc genes.3 “Here, we characterize a previously unrecognized nuclease, Fanconi anemia?associated nuclease 1 (FAN1), that promotes ICL repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the ID complex,” they said, referring to the tagging of a repair site with ubiquitin, a “ubiquitous” cellular tag signaling a site for repair or demolition. “Thus, the mono-ubiquitylated ID complex recruits the downstream repair protein FAN1 and facilitates the repair of DNA interstrand cross-links.” For more on DNA repair teams in the cell, see the 07/18/2001, 07/26/2002, 01/30/2003, 02/13/2004, 03/31/2005, 08/14/2007, and 03/14/2010 entries.These three papers are examples of many that are continuously being published in leading journals that (1) explore highly-specific molecules involved in vital cellular processes and (2) say nothing about evolution. Examples could be easily multiplied.1. Kaya and Higuchi, “Nonlinear Elasticity and an 8-nm Working Stroke of Single Myosin Molecules in Myofilaments,” Science, 6 August 2010: Vol. 329. no. 5992, pp. 686-689, DOI: 10.1126/science.1191484.2. Tsai, Manor et al, “Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes,” Science, 6 August 2010: Vol. 329. no. 5992, pp. 689-693, DOI: 10.1126/science.1192002.3. Liu, Ghosai, Yuan, Chen and Huang, “FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair,” Science, 6 August 2010: Vol. 329. no. 5992, pp. 693-696, DOI: 10.1126/science.1192656.Who needs evolution? Not these authors. Not medical science, genetics, or cell biology, either. Let’s move along, and leave Darwinism to rust in pieces.(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0 Reports continue to show that vital cell processes depend on finely-tuned proteins and RNA molecules. Most of the papers that discuss these specialized molecules fail to mention how they might have evolved, as shown in three papers in the recent issue of Science.
All 67 legislators of the Himachal Pradesh Vidhan Sabha, including Chief Minister Virbhadra Singh, Leader of the Opposition Prem Kumar Dhumal and Speaker Brij Bihari Lal Butail exercised their franchise in the presidential polls on Monday. The State has a 68-member Assembly but one seat is vacant following the death of Congress MLA Karan Singh.Independent membersSecretary of State Vidhan Sabha Sunder Lal Verma said that 35 Congress MLAs, 28 Bharatiya Janata Party MLAs and four Independent MLAs voted in the polls. Both the BJP and the Congress have claimed support of two Independent members each.Unicameral HouseIn the Unicameral House of the State, each MLA vote has a value of 51 votes and the State has four seats in the Lok Sabha — all occupied by the BJP. It also has three Rajya Sabha seats, one occupied by the BJP and the other two by the Congress. The Congress has a minor edge in the polls if no cross voting takes place.BJP meets GovernorRight after casting their votes, a delegation of the BJP met Governor Acharya Devvrat. Memo submittedThey submitted a memo urging him to dismiss the Virbhadra Singh-led government due to the “worsening law and order situation” in the State. Independent MLAs Balbir Verma and Manohar Dhiman, who recently joined the BJP, were part of the delegation.
Nikki Valdez rushes self to ER due to respiratory tract infection Pagasa: Kammuri now a typhoon, may enter PAR by weekend Don’t miss out on the latest news and information. Pablo tows Pocari past Perlas LOOK: Jane De Leon meets fellow ‘Darna’ Marian Rivera LATEST STORIES Young, 32, was the 16th overall selection in the 2007 NBA draft. He spent the past four seasons with the Lakers, and averaged 13.2 points in 60 games last season.That included connecting on more than 40 percent of his shots from three-point range. His addition adds depth to the talent-laden Warriors, who have won two of the past three NBA titles.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsESPN reported that Young would make $5.2 million for the one-year deal, slightly less than the $5.7 million he would have received from the Lakers. CBB Pagasa: Kammuri now a typhoon, may enter PAR by weekend View comments Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Nick Young (center), playing for the Lakers in this Nov. 27, 2016 photo, battles for the ball against Atlanta Hawks forward Kent Bazemore (left) and forward Thomas Robinson. APLOS ANGELES, United States — Guard Nick Young, a free agent since declining a player option with the Los Angeles Lakers, is headed to the NBA Champion Golden State Warriors.“Congratulations to @NickswagyPYoung on your new contract with the @warriors! We are so happy for you!” a tweet from Priority Sports, the agency that represents Young, said Wednesday.ADVERTISEMENT Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Sports Related Videospowered by AdSparcRead Next Lacson: SEA Games fund put in foundation like ‘Napoles case’ Another vape smoker nabbed in Lucena MOST READ China furious as Trump signs bills in support of Hong Kong
Is Luis Manzano planning to propose to Jessy Mendiola? Private companies step in to help SEA Games hosting Alvarez will face top lightweight contender Timofey Nastyukhin of Russia while Johnson, widely considered one of the best pound-for-pound fighters in history, will take on hometown bet Yuya Wakamatsu in the card.In the other blockbuster title bouts, Xiong Jing Nan faces challenger Angela Lee, who is looking for to become ONE’s first two-division champion, in the ONE women’s strawweight bout while Myanmar hero Aung La N Sang defends his middleweight strap against Ken Hasegawa out of JapanThe ONE Flyweight World Grand Prix will also kick off at ONE: A New Era with initial bouts yet to be announced.ADVERTISEMENT SEA Games: Biñan football stadium stands out in preparedness, completion LATEST STORIES Don’t miss out on the latest news and information. ONE Championship is pulling out all the stops for its debut card in Japan.ADVERTISEMENT SEA Games: Biñan football stadium stands out in preparedness, completion TS Kammuri to enter PAR possibly a day after SEA Games opening Hotshots rule PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Sports Related Videospowered by AdSparcRead Next Lacson: 2019 budget delay due to P75-B House ‘insertion’ The premier mixed martial arts organization have put together a slambang ONE: A New Era fight night on March 31 that will see three world title defenses and the first appearance of ONE Championship’s two prized recruits.Team Lakay bet Eduard Folayang is set to defend his ONE lightweight world title against the same person he stopped to get the crown in 2016.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSUrgent reply from Philippine football chiefFolayang will face Japanese icon Shinya Aoki in a long-awaited rematch for the belt four months after the Bagui0-native recaptured the lightweight throne with a unanimous decision win over Amir Khan.Demetrious Johnson and Eddie Alvarez, the promotion’s biggest signings last year, are also scheduled to make their much-awaited debut in the ONE Championship cage. Hotel management clarifies SEAG footballers’ kikiam breakfast issue LOOK: Joyce Pring goes public with engagement to Juancho Triviño MOST READ View comments
But FIFA has now concluded that it lacked to the time to prepare a country to host the extra games.In Kuwait, Jaber Al-Ahmad International Stadium has 60,000 seats and the capacity at Sabah Al-Salem Stadium is only 26,000. Both venues would require upgrades to be used at the World Cup, putting the spotlight on working conditions and labor rights.FIFA Secretary General Fatma Samoura wrote to human rights activists last month to offer assurances that there was going to be “an assessment of human rights risks and potential opportunities associated with a possible expansion.”Qatar has an exemption that allows foreigners to drink alcohol, but Kuwait has a complete ban which would have be problematic for FIFA, which has Budweiser as a major sponsor.FIFA has already had to adapt to cope with taking its showpiece tournament to the Middle East for the first time.ADVERTISEMENT Cayetano: Senate, Drilon to be blamed for SEA Games mess Private companies step in to help SEA Games hosting While Qatar won a vote in 2010 on the basis of staging a June-July World Cup, FIFA shifted the tournament to from its usual slot because of the fierce summer heat to Nov. 21-Dec 18, 2022.Sports Related Videospowered by AdSparcRead Next MOST READ Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue LATEST STORIES DA eyes importing ‘galunggong’ anew Don’t miss out on the latest news and information. Rudy Gobert, Paul George, Giannis Antetokounmpo headline NBA All-Defensive teams ‘Rebel attack’ no cause for concern-PNP, AFP People watch the inauguration ceremony, Thursday, May 16, 2019, of the Al Wakrah stadium, which is the first stadium has been built from the scratch for the 2022 FIFA World Cup in Doha, Qatar. (AP Photo/Kamran Jebreili)FIFA scrapped plans to expand the 2022 Qatar World Cup to 48 nations, deciding Wednesday to stick with 32 countries due to the political and logistical complexities of using another Persian Gulf nation.FIFA President Gianni Infantino’s hopes of expanding the Middle East’s first World Cup in the region were stymied by the regional diplomatic crisis and the governing body’s demands on host nations to adhere to its human and labor rights requirements. That means the World Cup will not be expanded until 2026, with FIFA already having approved a format with 48 teams for that tournament in the United States, Canada and Mexico.ADVERTISEMENT Robredo calls for scrapping of ‘Oplan Tokhang’ PLAY LIST 02:34Robredo calls for scrapping of ‘Oplan Tokhang’00:50Trending Articles00:50Trending Articles02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Two-day strike in Bicol fails to cripple transport Duterte wants probe of SEA Games mess A meeting of the FIFA Council in March authorized Infantino to work with Qatar on seeing if it was feasible to use at least one more country in the region to accommodate an additional 16 matches and present a proposal at meetings in June.“Following a thorough and comprehensive consultation process with the involvement of all the relevant stakeholders, it was concluded that under the current circumstances such a proposal could not be made now,” FIFA said in a statement on Wednesday. “Due to the advanced stage of preparations and the need for a detailed assessment of the potential logistical impact on the host country, more time would be required and a decision could not be taken before the deadline of June. It was therefore decided not to further pursue this option.”FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsA FIFA internal report had already concluded that the United Arab Emirates, Bahrain and Saudi Arabia could not join as co-hosts unless they restore the economic and travel ties with Qatar that were severed two years ago.The regional diplomatic crisis left neutral Kuwait and Oman as the viable options. Oman has said it isn’t keen on hosting games at the FIFA showpiece. Infantino visited Kuwait last month in an attempt to persuade them to host matches in 2022. Catholic schools seek legislated pay hike, too View comments