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Pasadena Assemblyman Pushes Bill to Require Police to Stop Excessive Force They Witness

first_img Community News More Cool Stuff CITY NEWS SERVICE/STAFF REPORT Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday Government Pasadena Assemblyman Pushes Bill to Require Police to Stop Excessive Force They Witness CITY NEWS SERVICE Published on Wednesday, July 22, 2020 | 5:02 pm Community News EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Your email address will not be published. Required fields are marked * Herbeauty10 Of The Most Notorious Female Spies In HistoryHerbeautyHerbeautyHerbeautyRed Meat Is Dangerous And Here Is The ProofHerbeautyHerbeautyHerbeautyHe Is Totally In Love With You If He Does These 7 ThingsHerbeautyHerbeautyHerbeauty11 Signs Your Perfectionism Has Gotten Out Of ControlHerbeautyHerbeautyHerbeautyA Mental Health Chatbot Which Helps People With DepressionHerbeautyHerbeautyHerbeauty6 Lies You Should Stop Telling Yourself Right NowHerbeautyHerbeauty faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,Virtual Schools PasadenaHomes Solve Community/Gov/Pub SafetyPasadena Public WorksPasadena Water and PowerPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Name (required)  Mail (required) (not be published)  Website  Assemblyman Chris Holden, D-Pasadena, introduced legislation Wednesday that would require police officers to physically stop excessive force they witness by another member of law enforcement and report the incident in real time to the dispatch or watch commander on duty.Holden’s office said the law currently requires officers in California to intervene when they observe another officer use force beyond what is necessary, but there are not universal measures to determine that the officer actually intervened.“We were outraged when we watched the killing of George Floyd by a Minneapolis police officer from a knee to the neck,” Holden said. “Equally disturbing, was the lack of intervention from the police officers who witnessed a clear use of excessive force.”The legislation — AB 1022 — would:• prohibit retaliation against law enforcement officers that report violations of law or regulation of another officer to a supervisor;• require an officer who fails to intercede to be disciplined in the same manner as the officer who used excessive force;• establish a website that makes specified public records of officers available in a form searchable by each officer’s name, and allows members of the public to file citizen complaints;• disqualify a person from being an officer if they have been found by a law enforcement agency that employs them to have either used excessive force that resulted in great bodily injury or death or to have failed to intercede in that incident as required by a law enforcement agency’s policies;• make an officer who is present and sees another officer using excessive force, and fails to intercede as required by the policy of their employing law enforcement agency, despite having a present ability to intercede, an accessory in any crime committed by the other officer during the use of excessive force.Holden represents California’s 41st Assembly District, which includes most of the San Gabriel Mountains and various foothill communities in Los Angeles County, and some areas of San Bernardino County.center_img Business News STAFF REPORT Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy Make a comment 18 recommended0 commentsShareShareTweetSharePin it STAFF REPORT First Heatwave Expected Next Week Top of the News Subscribe Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadenalast_img read more

Gemini Therapeutics Debuts as Publicly Traded Precision Medicine Company Focused on Age-Related Macular Degeneration

first_img CAMBRIDGE, Mass.–(BUSINESS WIRE)–Feb 8, 2021– Gemini Therapeutics, a clinical stage precision medicine company developing innovative treatments for genetically defined age-related macular degeneration (AMD), today announced the completion of its business combination with FS Development Corp. (Nasdaq: FSDC), a special purpose acquisition company (SPAC) sponsored by Foresite Capital. Gemini Therapeutics, Inc., the resulting combined company, will commence trading its shares today on the Nasdaq Global Market under the symbol “GMTX.” Gross proceeds from this transaction totaled approximately $216 million, which included funds held in FSDC’s trust account and the concurrent private investment in public equity (PIPE) financing. The shareholders of FSDC approved the transaction on February 3, 2021. The transaction was previously approved by Gemini Therapeutics’ shareholders. Gemini Therapeutics’ management team will continue to be led by Chief Executive Officer Jason Meyenburg. “We could not be more excited to enter the capital markets as a leading-edge precision medicine company focused on pioneering first-in-class medicines intended to restore regulation of the complement system in the eye and throughout the body,” said Mr. Meyenburg. “I want to thank all those involved in making this transaction a success, including our new and existing investors, and the Gemini and FSDC teams.” “Gemini’s impressive work with patients losing their vision because of genetically driven macular degeneration is the reason we knew they were the right candidate to merge with FSDC,” said Jim Tananbaum, M.D., Chief Executive Officer of Foresite Capital and President and Chief Executive Officer of FS Development Corp. “We are excited about the potential to help further develop innovative new treatment options for patients.” Summary of Transaction On October 15, 2020, Gemini Therapeutics, a privately held biotechnology company, entered into a definitive business combination agreement with FS Development Corp., a SPAC sponsored by Foresite Capital, that was created for the purpose of entering into a business combination with a biopharmaceutical company focused on the next generation of medicines utilizing genetics. As a result of the business combination, Gemini Therapeutics received proceeds of approximately $216 million, prior to transaction expenses, which includes cash proceeds of approximately $121 million from FSDC’s trust account (after redemptions of $1,200) and $95 million from PIPE investors led by Foresite Capital, as well as Fidelity Management & Research Company LLC, Wellington Management, Boxer Capital of Tavistock Group, Alyeska Investment Group, L.P., Suvretta Capital Management, CVF, DAFNA Capital, and Acorn Bioventures, in addition to existing Gemini Therapeutics shareholders including Orbimed Healthcare Fund Management, Atlas Venture, Lightstone Ventures and Wu Capital. The description of the business combination contained herein is only a high-level summary and is qualified in its entirety by reference to the underlying documents filed with the U.S. Securities and Exchange Commission. A more detailed description of the terms of the transaction has been provided in a registration statement on Form S-4 filed with the U.S. Securities and Exchange Commission by FSDC. Advisors Jefferies LLC and SVB Leerink acted as co-lead private placement agents for FS Development Corp. Jefferies LLC also acted as lead financial and capital markets advisor to FS Development Corp. Goldman Sachs & Co. LLC acted as lead financial advisor to Gemini in the transaction. Stifel acted as additional capital markets advisor to Gemini. Goodwin Procter LLP acted as legal counsel to Gemini. White & Case LLP acted as legal counsel to FS Development Corp. About GEM103 Gemini’s lead program, GEM103, is a pioneering precision medicine approach, targeting trial enrichment with genetically-defined patients. GEM103 targets a genetically-defined subset of age-related macular degeneration (AMD) patients with complement dysregulation. Of the 15 million dry AMD patients, approximately 40% (or six million) have variants in the complement factor H (CFH) gene. Such loss-of-function variants are associated with increased dry AMD disease risk. GEM103 is believed to be the first ever recombinant native complement modulator, full-length recombinant complement factor H (rCFH) protein. When delivered by intravitreal injection, GEM103 has the potential to address unmet medical need in genetically-defined subsets of AMD patients by circumventing dysfunctional CFH loss-of-function variants and slowing the progression of their retinal disease. About Dry Age-Related Macular Degeneration (AMD) Age-related macular degeneration (AMD) is a progressive retinal disease affecting millions of older adults, and the leading cause of irreversible blindness in the western world. Symptoms, which include blurry vision, loss of night vision and loss of central vision, make activities of daily living such as reading, driving and even recognizing faces progressively more difficult. Third-party reports indicate there are approximately 16 million patients with AMD in the United States alone. Dry AMD, which results from an interaction of environmental and genetic risk factors, represents about 90% of that population (or about 15 million) in the US compared to about 1.4 million with wet AMD. Genetic risk of developing dry AMD is significant, with approximately 70% attributable risk of advanced disease to heritability, while aging and smoking confer the strongest non-genetic risk. CFH risk variants occur in approximately 40% of patients with dry AMD and these patients have a significantly increased risk of developing the disease as well as progression from intermediate AMD to GA. The complement system, of which CFH is a modulator, is dysregulated in patients with these risk variants, and results in amplification of aberrant inflammatory responses in the eye. Over time, this dysregulation leads to damage to the macular region of the retina. About Gemini Therapeutics Gemini Therapeutics is a clinical stage precision medicine company developing novel therapeutic compounds to treat genetically defined age-related macular degeneration (AMD). Gemini’s lead candidate, GEM103, is a recombinant form of the human complement factor H protein (CFH), and is designed to address both complement hyperactivity and restore retinal health in patients with AMD. GEM103 is currently in a Phase 2a trial in dry AMD patients with a CFH risk variant. The company has generated a rich pipeline including recombinant proteins, gene therapies, and monoclonal antibodies. For more information, visit www.geminitherapeutics.com. Forward-Looking Statements Certain statements in this press release and the information incorporated herein by reference may constitute “forward-looking statements” for purposes of the federal securities laws. Our forward-looking statements include, but are not limited to, statements regarding our or our management team’s expectations, hopes, beliefs, intentions or strategies regarding the future, including those relating to the success, cost and timing of our product development activities and clinical trials, including our estimates regarding when data will be reported from ongoing clinical trials and the timing to commence future clinical trials, the potential attributes and benefits of our product candidates, including GEM103, our ability to obtain and maintain regulatory approval for our product candidates and our ability to obtain funding for our operations when needed. Forward-looking statements include statements relating to our management team’s expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements are based on current expectations and beliefs concerning future developments and their potential effects. There can be no assurance that future developments affecting us will be those that we have anticipated. These forward-looking statements involve a number of risks, uncertainties (some of which are beyond our control) or other assumptions that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements. These risks and uncertainties include, but are not limited to, those factors described under the heading “Risk Factors” in the final proxy/prospectus for our recently completed business combination, and those that are included in any of our future filings with the SEC. Should one or more of these risks or uncertainties materialize, or should any of our assumptions prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. Some of these risks and uncertainties may in the future be amplified by the COVID-19 pandemic and there may be additional risks that we consider immaterial or which are unknown. It is not possible to predict or identify all such risks. Our forward-looking statements only speak as of the date they are made, and we do not undertake any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. View source version on businesswire.com:https://www.businesswire.com/news/home/20210208005228/en/ CONTACT: Gemini Investor Contact:Argot Partners Sherri Spear 212-600-1902 [email protected] Media Contact:Argot Partners Joshua R. Mansbach 212-600-1902 [email protected] KEYWORD: MASSACHUSETTS UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: HEALTH GENETICS GENERAL HEALTH CLINICAL TRIALS PHARMACEUTICAL OPTICAL BIOTECHNOLOGY SOURCE: Gemini Therapeutics Copyright Business Wire 2021. PUB: 02/08/2021 07:00 AM/DISC: 02/08/2021 07:01 AM http://www.businesswire.com/news/home/20210208005228/en By Digital AIM Web Support – February 8, 2021 WhatsApp Facebook Gemini Therapeutics Debuts as Publicly Traded Precision Medicine Company Focused on Age-Related Macular Degeneration WhatsApp Previous articleHip Hop Hall of Fame Café & Museum Gallery to Open in Harlem, NYC in 2021 With Hip Hop “History” and “Activism Black Lives Matter” Exhibits – Post Covid VaccineNext articleNext-Gen Proteomics Company Nautilus Biotechnology to List on Nasdaq Through Merger with Arya Sciences Acquisition Corp III Digital AIM Web Support Twittercenter_img Twitter Local NewsBusiness Pinterest Facebook Pinterest TAGS  last_img read more

What Commandment Would An Act of God Star Sean Hayes Add?

first_img An Act of God It’s divine intervention! Will & Grace Emmy winner and stage and screen fave Sean Hayes will play the Big Man Upstairs in An Act of God, which begins previews on May 28 at the Booth Theatre. God himself appeared on The Today Show on May 25 to discuss his own holy requests for mankind. When asked which commandment he would add to the sacred ten, Hayes said, “Drive better!” He also went on to reveal his trick for forgetting lines during his 90-minute stint onstage. Watch the heavenly, hilarious interview below! Sean Hayes Sean Hayes View Commentscenter_img Show Closed This production ended its run on Sept. 4, 2016 Star Files Related Showslast_img read more

DHT: Financing sustainable tourism development – the topic of this year’s Croatian Tourism Forum

first_imgFIRST DHT ON THE CONTINENT: THREE DAYS OF RICH PROGRAM AT THE DAYS OF CROATIAN TOURISM IN SLAVONIA “The sustainability of our tourism, the tourism industry and financial institutions focused on tourism financing are closely interconnected and interdependent. In this context, our intention is to correctly set long-term sustainable goals, the achievement of which will achieve stability and predictability of tourism development.”, Said the President of the Croatian Chamber of Commerce Luka Burilović on the occasion of the Croatian Tourist Forum. The forum will bring together the business, institutional and financial sectors to discuss the challenges of sustainable tourism development and the importance of further investment in high-quality tourism infrastructure and offerings. Find out more details about the Croatian Tourism Day program in Slavonia in the attachment. On the third day of the event, as part of the 19th Croatian Tourist Forum organized by the Croatian Chamber of Commerce. Having in mind the challenges of sustainable tourism development as well as the importance of further investments in high-quality tourism infrastructure and offer, this year’s panel was dedicated to the financing of the tourism sector called Financing the sustainable development of tourism.  HTF will be held on October 4.10, 12 – 13: 30h, in Tvrđa, in Osijek. RELATED NEWS: The panel will be attended by: Victoria Zinchuk, EBRD Director in Croatia, Anton Kovačev, Head of the EIB Zagreb Office, Boris Bekavac, President of the Economy Committee of the Association of HGK Banks (TBC), Josipa Jutt, President of the HGK Hotel Association, Cluster General Manager, Hilton International, Frano Matošić, State Secretary, Ministry of Tourism, Ivo Kunst, Institute of Tourism, Marko Jurčić, Advisor to the President of the Croatian Chamber of Commerce, moderator. Photo: Pixabay.com Representatives of the Croatian tourism sector will gather from October 2nd to 5th in Slavonia for the first continental Days of Croatian Tourism, organized by the Ministry of Tourism, the Croatian Chamber of Commerce and the Croatian Tourist Board. last_img read more

German Pensionskassen, BaFin in ‘uncharted territory’ over solvency

first_imgThe German pension fund for a Catholic aid organisation in Cologne is one of three Pensionskassen in talks with the country’s regulator BaFin regarding the potential impact of 2017 losses.The €546m Caritas Pensionskasse (Caritas PK) is currently discussing its 2017 balance sheet “in close coordination with the actuary, the accountants and the BaFin”, the pension fund told IPE in a statement.Last week, BaFin issued a statement saying it had banned Caritas PK from taking on any new business since May, after finding that its recovery plan for meeting its solvency requirements was “inadequate”.It is the first time BaFin has issued a Pensionskasse with such a ban. However, over the past year the regulator has frequently issued warnings to insurance-based pension funds regarding their funding structures. BaFin’s office in BonnA detailed account of the solvency issues will only become available once the annual reports for both pension funds have been approved. A spokesperson for Caritas PK told IPE that its annual report would only be published once the general assembly had approved it. However, the general assembly was not due to hold another meeting this year, the spokesperson said.Industry sources told IPE that it was unlikely the Caritas PK would take on new business any time soon.Kölner PK blames rulebookThe Kölner PK is also currently not taking on any new business as it lacks funding to continue operations under the regulatory framework for mutual insurance companies.If this situation continues, the fund will have to start planning for internal runoff.In its 2016 annual report the Kölner PK’s board blamed – in part – “nonsensical measures” deriving from regulation for starting the fund’s solvency problems.Some regulatory requirements had forced the fund to sell off assets at the wrong point in time, the pension fund said, while some money put aside for the Zinszusatzreserve – the interest rate buffer – could have been better spent on filling the funding pool. Germany’s Bundesrat building in BerlinThe regulatory burden and reporting requirements for Pensionskassen and other German pension vehicles are unlikely to reduce any time soon.Germany’s lower chamber of parliament, the Bundestag, this month approved the government’s draft rules implementing the EU’s IORP II pension directive, known as the EbAV II.The pension fund association aba said “there is hope” that its objections to the prospect of EU-wide harmonisation for occupational pension funds had been heard.The draft bill has to be passed by the upper chamber of parliament (the Bundesrat) in a vote scheduled for today, with BaFin then due to issue circulars and guidelines on the actual implementation and industry-specific issues.What is already certain, however, is that the EbAV II will mean more reporting and internal risk assessment requirements for pension funds.“Overall the requirements for providers will increase significantly,” said Michael Hoppstädter, managing director of consultancy Longial.– Barbara Ottawa Earlier this year Caritas PK and its affiliated pension fund, the €329m Kölner Pensionskasse (Kölner PK), informed members about difficulties regarding the funding situation and possible cuts to pension payouts. Cologne’s Caritas and Kölner Pensionskassen face solvency problemsBoth the Caritas and Kölner funds are structured as mutual insurance companies – Versicherungsverein auf Gegenseitigkeit (VVaG) – which brings with it certain solvency and interest rate “buffer” requirements.The talks with BaFin now fall under the remit of Olaf Keese, who takes over joint management of the Caritas and the Kölner Pensionskassen this month. As a result of his appointment Keese will resign his seat on the board of the Peugeot pension fund in Germany at the end of the year.Tax consultants’ fund talking to BaFinFunding problems have also been reported at the pension fund for German tax consultants, the €992m Steuerberater Pensionskasse VVaG, with BaFin involved in negotiating a recovery plan. The fund itself declined comment.“All this is completely uncharted territory for the industry and the regulator,” one source told IPE.Insurance-based Pensionskassen had been performing well in Germany despite the funding requirements placed on them by their guarantees, but a mix of the low interest rate environment, challenging demographics and regulatory requirements has caught up with them.Some providers have chosen to sell their Pensionskassen business to run-off companies, with Frankfurter Leben having bought two funds earlier this year, from AXA Germany and Cofra Group.More regulation incoming as Bundestag passes IORP II billlast_img read more

Semenya switches to 200m in search of more Olympics glory

first_img Promoted Content7 Universities In The World With The Highest Market Value6 Extreme Facts About Hurricanes10 Risky Jobs Some Women Do10 Phones That Can Easily Fit In The Smallest Pocket11 Most Immersive Game To Play On Your Table TopWhich Country Is The Most Romantic In The World?Who Is The Most Powerful Woman On Earth?6 Great Ancient Mysteries That Make China Worth Visiting10 Phones That Can Work For Weeks Without RechargingTop 10 Tiniest Phones Ever Made7 Ways To Understand Your Girlfriend BetterCouples Who Celebrated Their Union In A Unique, Unforgettable Way Loading… FacebookTwitterWhatsAppEmail分享 Semenya is among a minority of female athletes who have an unusually high level of testosterone, which gives them added strength. The media-shy South African has faced constant legal battles during her career, leading to temporary bans from competing in her favourite 800m. The latest testosterone regulations left her with a choice of competing in the 200m or a distance longer than the mile. She has not returned impressive times over longer distances in the past, which prompted her to seek 200m qualification for Tokyo.center_img Read Also: Ronaldinho: Paraguay appeals court rejects release request Semenya must trim another 0.69 sec off her Pretoria time to secure a place in the South African Olympics team. The 200m world and Olympic records are held by American Florence Griffith-Joyner, who clocked 21.34 sec at the 1988 Seoul Olympics. Away from athletics, Semenya joined a Johannesburg-based football club last year but was unable to play immediately because she missed the registration deadline. Star South African 800-metre athlete Caster Semenya said on Friday she hopes to compete in the 200m at the 2020 Tokyo Olympic Games. South African Olympics champion Caster Semenya (R) wins the 200m final at a provincial championships in Pretoria Friday The 29-year-old is prohibited from defending her 800m Olympics title because she refuses to adhere to testosterone regulations set by governing body World Athletics. Semenya, and other female athletes with differences of sexual development (DSD), are banned from competing in races between 400m and the mile unless they take testosterone-lowering medication. She won the 2012 London and 2016 Rio Olympics 800m titles and was the world champion over the distance in 2009, 2011 and 2017. The South African must clock a 22.80-second 200m to qualify for Tokyo and her best time, achieved Friday in Pretoria when winning a provincial championships final, is 23.49 sec. “My dream has always been, and will continue to be, to compete at the highest level of sport,” Semenya said on her Instagram account. “So in order pursue my goals and dreams, I have decided to change events and compete in the 200m. “This decision has not been an easy one, but I look forward to the challenge, and will work hard, doing all I can to qualify for Tokyo and compete to the best of my ability for South Africa.” Semenya took the athletics world by storm 11 years ago when becoming world champion in Berlin at the age of 19. But as her list of successes lengthened, rival female athletes began to question how the South African could leave them trailing in her wake.last_img read more

Catholic priest robbed after leaving bank

first_imgA Catholic priest was robbed in front of his Oronoque Street, Queenstown, home on Tuesday afternoon after conducting business at a city bank.Catholic priest, Paul MartinReports are Father Paul Martin was robbed at gunpoint of cash and important documents at about 13:00h.According to a social media post by Catholic Media Guyana, as the priest exited his car in front of his driveway, another car stopped behind him from which a man exited, pointed a gun at him and demanded the bag, which contained the cash. The priest complied and handed over the bag, after which the gunman reentered the car and fled the scene. The matter was reported to the police.last_img read more

Specialized Molecules Make Cells Work

first_imgWalker with muscle:  A paper by Kaya and Higuchi from the University of Tokyo discussed how myosin motors, the active force-generating machines in muscle, adjust their walking steps with non-linear elasticity.1  Myosins work together in muscle.  Their ability to reduce stiffness and adjust their walk is essential: “the load-dependent changes in the step size are an essential property of skeletal myosin,” the authors said.  Their last sentence explained why this contributes to their effectiveness: “Such molecular properties may be inherent in the assembly of molecular motors and may reduce molecular interference, leading to the high mechanical efficiency of muscle contraction.”  You have your elastic myosins to thank for every simple or complex move you make.  For more stories about myosin this year, see 04/19/2010, 02/19/2010, and 01/19/2010.Junk with control:  It wasn’t long ago when any non-coding region of the genome was considered junk.  No longer; lincRNAs are emerging as stars of regulation and control (see 08/02/2010).  Another finding to that effect was published in Science by an international team from Stanford, Harvard and the Weizmann Institute in Israel.2  They studied one lincRNA called HOTAIR that has two specific binding domains for making histone modifications.  Histone is the protein on which DNA winds.  It contains molecular tags that affect translation – the “histone code” (see 12/22/2009, bullet 5, with its embedded links).    The team found that HOTAIR, an RNA generated from non-coding DNA, is intimately involved with the regulation of histone by forming a scaffold for PRC2 and LSD1 proteins: “The functional consequence of coordinate targeting of PRC2 and LSD1 by HOTAIR is gene repression,” they said.  What they found may apply to other cases: “Some lincRNAs may be ‘tethers’ that recruit several chromatin modifications to their sites of synthesis while other lincRNAs can act on distantly located genes as ‘guides’ to affect their chromatin states,” the concluded.  “On the basis of their dynamic patterns of expression, specific lincRNAs can potentially direct complex patterns of chromatin states at specific genes in a spatially and temporally organized manner during development and disease states.”Repairmen with teamwork:  A team at Zheijiang University in China studied the partners in DNA interstrand cross-link repair, one of many repair pathways active in the genome.  Fanconi anemia is a disease caused by mutations in 13 Fanc genes.3    “Here, we characterize a previously unrecognized nuclease, Fanconi anemia?associated nuclease 1 (FAN1), that promotes ICL repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the ID complex,” they said, referring to the tagging of a repair site with ubiquitin, a “ubiquitous” cellular tag signaling a site for repair or demolition.  “Thus, the mono-ubiquitylated ID complex recruits the downstream repair protein FAN1 and facilitates the repair of DNA interstrand cross-links.”    For more on DNA repair teams in the cell, see the 07/18/2001, 07/26/2002, 01/30/2003, 02/13/2004, 03/31/2005, 08/14/2007, and 03/14/2010 entries.These three papers are examples of many that are continuously being published in leading journals that (1) explore highly-specific molecules involved in vital cellular processes and (2) say nothing about evolution.  Examples could be easily multiplied.1.  Kaya and Higuchi, “Nonlinear Elasticity and an 8-nm Working Stroke of Single Myosin Molecules in Myofilaments,” Science, 6 August 2010: Vol. 329. no. 5992, pp. 686-689, DOI: 10.1126/science.1191484.2.  Tsai, Manor et al, “Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes,” Science, 6 August 2010: Vol. 329. no. 5992, pp. 689-693, DOI: 10.1126/science.1192002.3.  Liu, Ghosai, Yuan, Chen and Huang, “FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair,” Science, 6 August 2010: Vol. 329. no. 5992, pp. 693-696, DOI: 10.1126/science.1192656.Who needs evolution?  Not these authors.  Not medical science, genetics, or cell biology, either.  Let’s move along, and leave Darwinism to rust in pieces.(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0 Reports continue to show that vital cell processes depend on finely-tuned proteins and RNA molecules.  Most of the papers that discuss these specialized molecules fail to mention how they might have evolved, as shown in three papers in the recent issue of Science.last_img read more

Nestlé nurtures future footballers

first_imgNestlé’s Milo brand is getting behind football in South Africa by supporting its development in schools. (Image: Nestlé Milo) MEDIA CONTACTS • Ravi PillayNestlé public affairs manager+27 11 889 6799 or + 27 82 908 2580RELATED ARTICLES • SA’s children get football fever • Peace football tournament for SA • Football for Hope to unite SA • Fly the Flag for Football toolkitJanine ErasmusThe 2009 Nestlé Milo Champions tournament brought almost 6 000 schools from around South Africa together in Soweto to compete for the trophy, as well as R100 000 (US$13 300) for the winning school to invest in a health, wellness or nutrition initiative.With the 2010 Fifa World Cup now scant months away, football fever in all forms is gripping the nation as never before. Last year’s Milo Champions competition, run in collaboration with the South African Schools Football Association (Sasfa) and the Supersport television channel, was the second edition.About 94 500 would-be football stars participated in the 2009 tournament, with around 75 000 children from some 4 800 schools taking part in the 2008 event.Dorothy Langa Primary School in Limpopo province was the ultimate winner, snatching the title from Mpumalanga’s Mapula Sindane School in an exciting final that came down to a penalty shoot-out. Dorothy Langa, with two goals to Mapula’s one, emerged triumphant.“It is great to see that school competitions like this are not dominated by one school,” said Dorothy Langa head coach Mpho Mathopa. “Our achievement has reflected the true spirit of competition and shown that there is a balance of football talent in the country.”Developing future talentThe competition was open to all South African primary schools, and took place over four months. District and regional winners went through to the provincial play-offs, and the nine provincial winners progressed to the national finals at Hyundai Park in Soweto.“We want to see growth in school soccer in our country,” said Sasfa president Mandla “Shoes” Mazibuko. “Next year we will make sure that more schools take part in this wonderful tournament.”Global food giant Nestlé has invested generously in the Milo Champions tournament. In addition to the grand prize, each provincial winner walked off with R10 000 ($1 320), while the runner-up took home R75 000 and the third-placed team won R50 000 ($6 600).The programme is intended primarily to foster young football talent in South Africa while promoting an enthusiasm for the beautiful game and an awareness of the importance of healthy living. As well as valuable football coaching from top players, all participants received comprehensive nutritional education.Nestlé South Africa MD Yves Manghardt said, “We at Nestlé hope that each child who has played in this tournament comes out a winner, having learnt about teamwork, determination and most importantly why sports and a healthy lifestyle are qualities that will stand them strong through life.”Nurturing football skillsDorothy Langa chose to use the money for a new football field, which was officially opened towards the end of 2009. The 68m x 50m field, complete with borehole to ensure that the pitch is always green, was a welcome addition to the school’s infrastructure.To celebrate the occasion former Bafana Bafana defender Mark Fish gave a coaching clinic at the school. Fish is Nestlé’s Milo brand ambassador for good health, and also took time to visit each of the nine finalists beforehand to help with their preparations for the big day.At the same time Nestlé launched the South African branch of its Healthy Kids programme. This is a global initiative that aims to fight the growing problem of malnutrition and obesity in children between the ages of four and 16. By encouraging good nutrition and exercise, Healthy Kids aims to raise a healthier, more active generation.The programme was introduced to the world in April 2009 by Nestlé CEO Paul Bulcke.Regional competitionIn anticipation of the first World Cup to take place on African soil, the Milo brand is deepening its association with football in South Africa by extending the Champions tournament to the entire African continent.The inaugural African Milo Champions tournament was launched in September 2009 and features top under-13 teams from Nigeria, South Africa, Kenya, Ghana and Cote d’Ivoire. Regional stages are already underway, and the final will take place in South Africa in May 2010, just before the month-long Fifa World Cup kicks off in June.last_img read more

Groundspeak’s ‘Kitchen of Affirmation’

first_imgLetters to Groundspeak The kitchen at Groundspeak is stocked with pretty much the standard condiments and food you’d find in any kitchen.  The fridge is home to ketchup and mustard and some random unlabeled containers.  The corner coffeemaker generates a little morning rush hour traffic as Lackeys clamor for a cup of morning energy.But this week, Lackeys walked into the kitchen recently and walked out with more than coffee. It’s what appeared on the cabinets that gave those leaving, coffee mug in hand, with a feeling of affirmation.Letters taped to the cabinets read, “Once again your donation is making school cool” and “I also want to thank you for donating to our class.  I think it is the sweetest thing anyone did to our class.”Groundspeak donates money for GPS devices to a cause called DonorsChoose.org.  The donations put GPS devices in the hands of students.The Lost & Found video crew visited a Texas, USA class that received a donation of GPS devices.  You can watch how a teacher intertwined a lesson plan about science with the outdoor adventure of geocaching.The students went geocaching.  They solved problems in small groups, learned direction and distance, and engaged with technology.More than 30 letters from different classrooms have arrived at Groundspeak over the past year and we are committed to putting more GPS unites in the hands of students.Letter to GroundspeakA half-dozen thank you letters from students are on display in the kitchen now.  One line from a grade school student reads, “Thank you thank you thank you (1,000,000,000 times) much for donating to our class.”   How the letters are signed may say more.   Some of the chunky grade school writing spells out “thank you” or “your friend” or even “love.”But students aren’t just thanking Lackeys.  They’re not just affirming that geocaching can be a powerful force for learning.  They’re thanking geocachers for making this donation possible.  You fuel Groundspeak.  Those letters of thanks (a 1,000,000,000 times much) are really written to you as well.Share with your Friends:More SharePrint RelatedTeaching Geocaching and a Lackey to Complete a 5/5November 22, 2011In “Community”Refer a Friend – Help Kids Learn about GPSMay 25, 2011In “Learn”GeoWoodstock IX 2011 – A Lackey Report from PennsylvaniaAugust 19, 2011In “Community”last_img read more